Information about "GUTS, a comprehensive guide"
This page contains information
about the e-book on GUTS
entitled: "Modelling survival under chemical stress. A
comprehensive guide to the GUTS framework." The first
version was released on 18 January 2018. This book is
co-written by Tjalling
Jager and Roman
Ashauer, as part of a Cefic-LRI
funded project. The book contains a detailed
description of GUTS (both conceptual and mathematical), its
special cases, and the associated statistics. Case studies
will be included to illustrate how to use GUTS on actual
data sets, and much, much more.
The book is offered through the Leanpub publishing
framework. As with the other e-books,
you have the opportunity to download it for free, but you
also have the option to pay for it. Please consider this
option, for it will allow us to dedicate time and effort to
updating this e-book, and writing new ones. In any case, it
is good to download this e-book from Leanpub yourself, as
you will be informed automatically when we release a new
- You can download the e-book from this landing page at
Leanpub (Version 3.0 of 20 July 2023) or check out the first 15 pages
- Check the version/error
log for changes relative to the previous version,
known errors in the current version, and parts that we
will modify/clarify in the next update. If you need an
old version of the book, just contact me (all versions are
- Check out the list of survival papers over here. At this
moment, the list only contains papers using the hazard
formulation (i.e., GUTS-SD, GUTS-RED-SD, and its
How do I refer to the book?
Please refer to the Leanpub page
with the version of the PDF. E.g.:
As general reference to GUTS, you can use the paper in the
- Jager T and Ashauer R (2023). Modelling survival under
chemical stress. A comprehensive guide to the GUTS
framework. Version 3.0. Toxicodynamics Ltd., York, UK.
Available from Leanpub: https://leanpub.com/guts_book.
- Jager T, Albert C, Preuss TG and Ashauer R (2011).
General Unified Threshold model of Survival - a
toxicokinetic-toxicodynamic framework for ecotoxicology.
Environ Sci Technol 45:2529-2540. http://dx.doi.org/10.1021/es103092a
Where can I find software to do 'GUTS' analyses?
In 2018/2019 we have developed the
free, open source, user-friendly, Windows-based, standalone
software openGUTS in a
funded project. In my (admittedly biassed) opinion,
this is the best GUTS software out there. There is also a
Matlab version of openGUTS with the same engine and roughly
the same functionality, which served as the blueprint and
testing platform for the standalone software. Both can be
downloaded from the dedicated openGUTS website.
OpenGUTS only contains the simplest GUTS cases GUTS-RED-SD
There is also a BYOM package for
GUTS that allows all GUTS cases to be run. Links to other
freely-downloadable software (such as two R-packages for
GUTS, a web-based application, and several other standalone
versions) are collected over here.
In the book, we also present the results from a ring test
with 11 software implementations. Not all of them are
freely-available yet (they will be included in the software
section of this website when they do), and several have
actually been discarded in the meantime.
Ring test information
Data sets used for the GUTS ring
test (as presented in Appendix A of the e-book) can be downloaded
here as Excel file.
A detailed listing of the parameter estimates and
predictions (with confidence intervals) for the BYOM analyses has been collected into
a report. Download
here. This is an updated version, using BYOM v. 4.2b
and GUTS v. 2.2 (both with a few updates to increase speed
and accuracy, and correcting a small error). There are some
differences with the earlier BYOM analysis (as went into the
e-book), which are discussed in the PDF. Filesize is pretty
large due to the parameter-space plots that I included. This
is the version of 19 August 2018 (note that the version of
15 Aug. 2018 contained a silly error in calculations
involving time-varying concentrations).
Making a print version of the e-book
Of course, you can always use a
print-on-demand service to produce a real book for you.
Roman used epubli (website seems
to be in German only) to produce a physical version of the
GUTS book v.3.0, as you can see below. The layout of the
e-books is such that it works well in the printed version,
and is readable at B5 size.