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E-books / Guide to GUTS

Information about "GUTS, a comprehensive guide"

This page contains information about the e-book on GUTS entitled: "Modelling survival under chemical stress. A comprehensive guide to the GUTS framework." The first version was released on 18 January 2018. This book is co-written by Tjalling Jager and Roman Ashauer, as part of a CEFIC-LRI funded project. The book contains a detailed description of GUTS (both conceptual and mathematical), its special cases, and the associated statistics. Case studies will be included to illustrate how to use GUTS on actual data sets, and much, much more.
The book is offered through the Leanpub publishing framework. As with the other e-books, you have the opportunity to download it for free, but you also have the option to pay for it. Please consider this option, for it will allow us to dedicate time and effort to updating this e-book, and writing new ones. In any case, it is good to download this e-book from Leanpub yoursefl, as you will be informed automatically when we release a new version.

You can download the e-book from this landing page at Leanpub (Version 1.0 of 18 January 2018) or check out the first 12 pages here.

   Check the version/error log for changes relative to the previous version, and known errors in the current version.

   Check out the list of survival papers over here. At this moment, the list only contains papers using the hazard formulation (i.e., GUTS-SD, GUTS-RED-SD, and its predecessors).

How do I refer to the book?

Please refer to the Leanpub page with the version of the PDF. E.g.:
  • Jager T and Ashauer R (2018). Modelling survival under chemical stress. A comprehensive guide to the GUTS framework. Version 1.0. Toxicodynamics Ltd., York, UK. Available from Leanpub:
As general reference to GUTS, you can use the paper in the open literature:
  • Jager T, Albert C, Preuss TG and Ashauer R (2011). General Unified Threshold model of Survival - a toxicokinetic-toxicodynamic framework for ecotoxicology. Environ Sci Technol 45:2529-2540. 

Where can I find software to do 'GUTS' analyses?

Matlab-based software packages are offered on the BYOM pages. All GUTS cases can be run. Links to other freely-downloadable software (such as two R-packages for GUTS) is collected over here. In the book, we also present the results from a ring test with 11 software implementations. Not all of them are available yet, but for many a freely-downloadable version is anticipated.

Ring test information

Data sets used for the GUTS ring test (as presented in Chapter 7 of the e-book) can be downloaded here as Excel file.

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