Welcome to the DEBtox information site
Welcome to the DEBtox information page, the
site for people that want to make sense of ecotoxicity data.
This site contains information on mechanistic models for the
analysis of stressor effects on the life-history traits of
individual organisms (and from there to higher and lower
levels of biological organisation). Specifically, this site
is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models
from the GUTS framework.
This website constitutes a node in the international DEBnet
network, together with the associated site of DEBtox Research.
The mission of DEBtox.info is to simplify biology to
get to the essence of what toxicants (and other stresses)
are doing to organisms. Simplification is necessary if we
need to gain understanding. Furthermore, we cannot expect to
test even a small fraction of all possible (combinations of)
toxicants, species and environmental conditions. Once we get
to the essence, it is possible to make educated predictions
of toxicant effects for untested chemicals, untested
species, and under untested conditions.
Here, you can find information, lists of relevant
publications, (links to) free e-books, and freely
downloadable Matlab packages to analyse your data. Use the
major categories on the top left of the screen to navigate
through this site; the corresponding sub-categories will
appear right next to it in the sub-menu.
Messages and warnings
The free and open-source software openGUTS v1.1 is
now available for download!
It is available as a standalone Windows executable
or as Matlab package. It supports the use of GUTS for regulatory
purposes, but will also prove useful for scientific
studies. The dedicated website http://openguts.info/
provides more information. Version 1.1 repairs a
calculation error that was spotted in
openGUTS, which may affect IT
calibrations/predictions for specific types
of exposure scenarios. The Matlab version
has also been updated to v1.1 to repair
this. For more information, see the openGUTS
For users of BYOM
versions before v. 4.3, see the notes and warnings
on the BYOM page (bottom of
page). But, really,
you should update to a newer version ... If you are
working with BYOM, and would like to be notified
immediately in case of errors, new versions, etc., email me and I will
include you in a mailing list. I may also use this
mailing list for other important developments such
as new (versions) of the e-books, and new papers.
This saves you the hassle of checking this website
every week ;-).
Upcoming courses and events
- Roman Ashauer and Tjalling Jager gave an on-line short
course on openGUTS
at the 2020 SETAC SciCon. This course is now available
for everyone via Leanpub: https://leanpub.com/c/openguts.
Although you don't get the interaction with the
instructors, this is still a nice way to educate
yourself in quarantine.
- The next DEB school and symposium is planned for the
first half of 2023. Excellent to get you started on
standard DEB and add-my-pet (not specifically focussing
on TKTD). More info available here.
- The next TKTD Autumn School on dynamic modelling of
toxic effects is provisionally planned for October 2023.
More info will become available here.
- The Preditox winter school, 30 January-3 February 2023
in Lyon (France), spends one day on TKTD modelling
(GUTS), among other data analysis tools. More
Job opportunities for TKTD/DEB modellers
- Syngenta is looking for a technical expert on TKTD
- Leiden University (the Netherlands) is looking for an
assistant professor in process-based ecotoxicology
(incl. DEB-based and TKTD). More
Older news over here.
- 4 July 2022: Take a look at the DeEP tool
for EPx predictions with DEBtox2019.
Note that this tool does not perform calibrations or
validations on data sets, but rather makes EPx
predictions for exposure profiles, such as those from
- 27 June 2022: Small update of BYOM to version 6.2.
Correcting a few errors when calculating ECx/EPx with
multiple parameter sets. See BYOM downloads page.
- 22 June 2022: version 1.0 of the stdDEB-TKTD package
is uploaded. See BYOM downloads page. Also today,
an MS for this model was submitted for publication.
- 17 June 2022: There will be another TKTD Autumn school
in 2023. Tjalling Jager and Roman Ashauer have decided
to step out of the teaching team, but a strong team
remains. More information will be presented or linked on
- 5 May 2022: Paper published on applying DEBkiss to
early-life stages of cleaner fish (https://doi.org/10.1016/j.ecolmodel.2022.110005
Open Access). Part of the StartRens
- 21 April 2022: Small update of the stdDEB-TKTD package
to version Beta 4. See BYOM downloads page.