Welcome to the DEBtox information site
Welcome to the DEBtox information page, the
site for people that want to make sense of ecotoxicity data.
This site contains information on mechanistic models for the
analysis of stressor effects on the life-history traits of
individual organisms (and from there to higher and lower
levels of biological organisation). Specifically, this site
is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models
from the GUTS framework.
This website constitues a node in the international DEBnet
network, together with the associated site of DEBtox Research.
The mission of DEBtox.info is to simplify biology to
get to the essence of what toxicants (and other stresses)
are actually doing to organisms. Simplification is necessary
if we need to gain understanding. Furthermore, we cannot
expect to test even a small fraction of all possible
(combinations of) toxicants, species and environmental
conditions. Once we get to the essence, it is possible to
make educated predictions of toxicant effects for untested
chemicals, untested species, and under untested conditions.
Here, you can find information, lists of relevant
publications, (links to) free e-books, and freely
downloadable Matlab packages to analyse your data. Use the
major categories on the top left of the screen to navigate
through this site; the corresponding sub-categories will
appear right next to it in the submenu.
The free and open-source software
openGUTS is now available for download!
It is available as a standalone Windows executable
or as Matlab package. It supports the use of GUTS for regulatory
purposes, but will also prove useful for scientific
studies. The dedicated website http://openguts.info/
provides more information.
In August 2020, we will again organise our
much-praised summer school "Dynamic modelling of
toxic effects" in Denmark. Registration is open, and
will close on 31 May 2020. See the course page. Download flyer.
WARNING! For users of BYOM, see the notes and
warnings on the BYOM page.
Specifically pertinent: the likelihood-region method
yielded exaggerated confidence intervals on model
predictions (fixed in version 4.2), and the LPx
calculations (used with GUTS, to calculate
multiplication factors on concentration profiles) is
biassed when there is substantial background
mortality in the calibration data set (fixed in
If you are working with
BYOM, and would like to be notified immediately in
case of errors, new versions, etc., email me and I will
include you in a mailing list. I may also use this
mailing list for other important developments such
as new (versions) of the e-books, and new papers.
This saves you the hassle of checking this website
every week ;-).
Upcoming courses and events
- Dedicated 2-day GUTS courses, geared towards
professionals in risk assessment of pesticides.
Wageningen, the Netherlands, dates to be announced. More information.
- Sandrine Charles is organising an extensive winter
school 6-10 January 2020 (in Lyon, France)
focussing on ecotox effect models.
- Roman Ashauer and myself will be giving a short course
on the openGUTS
software at the upcoming SETAC-Europe
conference in Dublin. This will be an afternoon's
hands-on course for using the software, so very limited
attention to the backgrounds of the GUTS model itself.
However, you should be able to combine out course with
Sandrine Charles' planned full-day course (which
dedicates its morning session to GUTS theory).
- In August 2020, we will again organise our
much-praised summer school "Dynamic modelling of toxic
effects" in Denmark. Registration is open, and will
close on 31 May 2020 (or when we reach the maximum
number of participants). More information on the course page; keep 10-19
August free! Download
Job opportunities for modellers
- Nothing at the moment (that I know of).
Older news over here.
- 11 Dec. 2019: new paper presenting an updated
simplified DEB model for ecotoxicology (based on
DEBkiss, compound parameters). See https://doi.org/10.1016/j.ecolmodel.2019.108904.
- 18 Sept. 2019: the GUTS course planned for October
2019 has been cancelled due to insufficient
- 2 Sept. 2019: update for BYOM and a new DEBtox2019
package (replacing DEBkiss-tox). See
the BYOM page.
- 24 May 2019: update for the BYOM DEBkiss-tox package.
This brings the package in line with v.2.0 of the DEBkiss e-book. See the BYOM page.
- 22 May 2019: update for the BYOM dose-response fitting
package for classical ECx estimates at a single time
point. See the BYOM page.
- 21 May 2019: new paper on effects of hydrogen peroxide
on shrimps, including GUTS analysis with pulsed
exposure. See https://doi.org/10.1016/j.ecoenv.2019.05.045.
- 17 May 2019: the openGUTS.info
website is now on-line. This site will host the openGUTS
standalone software, but already offers the Matlab
prototype for download.
- 9 May 2019: major update of the "Making sense of
chemical stress" e-book. The book is now up-to-date with
the streamlining of TKTD models that was started with
GUTS. More information.
- 23 April 2019: small update of BYOM to v. 4.3. Few
bugs fixed, but main change is explicit licensing
information included. More details on the BYOM page.