Welcome to the DEBtox information site
Welcome to the DEBtox information page, the
site for people that want to make sense of ecotoxicity data.
This site contains information on mechanistic models for the
analysis of stressor effects on the life-history traits of
individual organisms (and from there to higher and lower
levels of biological organisation). Specifically, this site
is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models
from the GUTS framework.
This website constitutes a node in the international DEBnet
network, together with the associated site of DEBtox Research.
The mission of DEBtox.info is to simplify biology to
get to the essence of what toxicants (and other stresses)
are doing to organisms. Simplification is necessary if we
need to gain understanding. Furthermore, we cannot expect to
test even a small fraction of all possible (combinations of)
toxicants, species and environmental conditions. Once we get
to the essence, it is possible to make educated predictions
of toxicant effects for untested chemicals, untested
species, and under untested conditions.
Here, you can find information, lists of relevant
publications, (links to) free e-books, and freely
downloadable Matlab packages to analyse your data. Use the
major categories on the top left of the screen to navigate
through this site; the corresponding sub-categories will
appear right next to it in the sub-menu.
Messages and warnings
The free and open-source software
openGUTS v1.1 is now available for download!
It is available as a standalone Windows executable
or as Matlab package. It supports the use of GUTS for regulatory
purposes, but will also prove useful for scientific
studies. The dedicated website http://openguts.info/
provides more information. Version 1.1 repairs a
calculation error that was spotted in
openGUTS, which may affect IT
calibrations/predictions for specific types
of exposure scenarios. The Matlab version
has also been updated to v1.1 to repair
this. For more information, see the openGUTS
For users of BYOM
versions before v. 4.3, see the notes and warnings
on the BYOM page (bottom of
page). But, really,
you should update to a newer version ... If you are
working with BYOM, and would like to be notified
immediately in case of errors, new versions, etc., email me and I will
include you in a mailing list. I may also use this
mailing list for other important developments such
as new (versions) of the e-books, and new papers.
This saves you the hassle of checking this website
every week ;-).
Upcoming courses and events
- 9-10 December 2021. GUTS modelling: from the theory to
the practice. On-line course via Zoom. This course
likely focuses on the Mosaic platform and Bayesian
- We planned to provide regular GUTS courses, but these
plans are put on ice for the moment. More information.
- Roman Ashauer and myself gave an on-line short course
on openGUTS at the
2020 SETAC SciCon. This course is now available for
everyone via Leanpub: https://leanpub.com/c/openguts.
Although you don't get the interaction with the
instructors, this is still a nice way to educate
yourself in quarantine.
- The next DEB school and symposium is planned for the
first half of 2023. More info will become available here.
- The next TKTD summerschool on dynamic modelling of
toxic effects is expected to be mid 2023. More info will
become available here.
Job opportunities for modellers
Older news over here.
- 25 November 2021: small update to beta 7 of BYOM,
available for download. The old version 5.2.
still remains available as well for a while.
- 15 November 2021: beta 6 version of BYOM available for
The old version 5.2. remains available as well for a
while, since the old files (and the current packages)
will not work anymore with the new BYOM version (in
general, only small modifications are needed).
- 28 August 2021: new e-book launched. Mechanistic
modelling essentials is now available from Leanpub. More
- 11 June 2021: our MultiCop
paper on growth in the copepod Tigriopus brevicornis
has been accepted for publication in J. Sea Res. No
complete DEB analysis yet, but highly relevant for
DEB-based studies of copepods. Available via the DOI.
- 4 May 2021: discussion paper on the use of
reproduction data in DEB-based models. This is a must
read for all TKTD modellers that work with reproduction
data! A preprint is available at bioRxiv.
Paper has been accepted 7 June for publication in IEAM.
Early view at http://doi.org/10.1002/ieam.4476.
- 25 February 2021: new version 1.1 of the openGUTS
software. See the
openGUTS downloads page.
- 9 February 2021: Error in the BYOM/engine files
calc_epx and calc_ecx when used in conjunction with the
slice sampler (in Bayesian analyses). The confidence
intervals take min-max of the output rather than
percentiles (they will thus be too wide). This will be
repaired in the next update of BYOM.
- 27 January 2021: New paper from Sylvain Bart on
mixtures with GUTS in ES&T, see https://doi.org/10.1002/ieam.4333.