DEBtox information
Making sense of ecotoxicity test results

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DEBtox information

DEBtox information


Welcome to the DEBtox information site

Welcome to the DEBtox information page, the site for people that want to make sense of ecotoxicity data. This site contains information on mechanistic models for the analysis of stressor effects on the life-history traits of individual organisms (and from there to higher and lower levels of biological organisation). Specifically, this site is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models from the GUTS framework.

This website constitutes a node in the international DEBnet network, together with the associated site of DEBtox Research.

The mission of  is to simplify biology to get to the essence of what toxicants (and other stresses) are doing to organisms. Simplification is necessary if we need to gain understanding. Furthermore, we cannot expect to test even a small fraction of all possible (combinations of) toxicants, species and environmental conditions. Once we get to the essence, it is possible to make educated predictions of toxicant effects for untested chemicals, untested species, and under untested conditions.

Here, you can find information, lists of relevant publications, (links to) free e-books, and freely downloadable Matlab packages to analyse your data. Use the major categories on the top left of the screen to navigate through this site; the corresponding sub-categories will appear right next to it in the sub-menu.

Messages and warnings

The free and open-source software openGUTS v1.1 is now available for download! It is available as a standalone Windows executable or as Matlab package. It supports the use of GUTS for regulatory purposes, but will also prove useful for scientific studies. The dedicated website provides more information. Version 1.1 repairs a
calculation error that was spotted in openGUTS, which may affect IT calibrations/predictions for specific types of exposure scenarios. The Matlab version has also been updated to v1.1 to repair this. For more information, see the openGUTS website.

For users of BYOM versions before v. 4.3, see the notes and warnings on the BYOM page (bottom of page).
But, really, you should update to a newer version ... If you are working with BYOM, and would like to be notified immediately in case of errors, new versions, etc., email me and I will include you in a mailing list. I may also use this mailing list for other important developments such as new (versions) of the e-books, and new papers. This saves you the hassle of checking this website every week ;-).

                DEBnet network of experts

The Duck of Vaucanson

Upcoming courses and events

  • Roman Ashauer and Tjalling Jager gave an on-line short course on openGUTS at the 2020 SETAC SciCon. This course is now available for everyone via Leanpub: Although you don't get the interaction with the instructors, this is still a nice way to educate yourself in quarantine.
  • The next DEB school and symposium is planned for the first half of 2023. Excellent to get you started on standard DEB and add-my-pet (not specifically focussing on TKTD). More info available here.
  • The next TKTD Autumn School on dynamic modelling of toxic effects is provisionally planned for October 2023. More info will become available here.
  • The Preditox winter school, 30 January-3 February 2023 in Lyon (France), spends one day on TKTD modelling (GUTS), among other data analysis tools. More information.

Job opportunities for TKTD/DEB modellers

  • Syngenta is looking for a technical expert on TKTD modelling. More information.
  • Leiden University (the Netherlands) is looking for an assistant professor in process-based ecotoxicology (incl. DEB-based and TKTD). More information.
  • ...

Latest news

  • 4 July 2022: Take a look at the DeEP tool for EPx predictions with DEBtox2019. Note that this tool does not perform calibrations or validations on data sets, but rather makes EPx predictions for exposure profiles, such as those from FOCUS.
  • 27 June 2022: Small update of BYOM to version 6.2. Correcting a few errors when calculating ECx/EPx with multiple parameter sets. See BYOM downloads page.
  • 22 June 2022: version 1.0 of the stdDEB-TKTD package is uploaded. See BYOM downloads page. Also today, an MS for this model was submitted for publication.
  • 17 June 2022: There will be another TKTD Autumn school in 2023. Tjalling Jager and Roman Ashauer have decided to step out of the teaching team, but a strong team remains. More information will be presented or linked on the course page.
  • 5 May 2022: Paper published on applying DEBkiss to early-life stages of cleaner fish ( Open Access). Part of the StartRens project.
  • 21 April 2022: Small update of the stdDEB-TKTD package to version Beta 4. See BYOM downloads page.
Older news over here.

The DEBtox information site,, since July 2011