Version log E-book "Making sense of chemical stress" Version Beta 1 (Date 9 April 2012) - First test version of this book. Version 1.0 (Date 14 June 2013) - Corrected spelling errors and addressed a few unclarities. - Added a few new references and minor additions to the text. - Added a short final chapter. - No major changes compared to the Beta 1 version, but I now feel confident enough about the contents to call this version 1.0. Version 1.1 (Date 15 October 2014) - Added a chapter with case studies that illustrate the 'DEBtox' aproach to data analysis (for Daphnia magna and Capitella teleta). - Increased the font size on the title page. - Few text errors corrected, small things clarified, and some recent references added. Version 1.2 (Date 11 August 2015) - Changed my affiliations, and I now publish it with Leanpub (which means some small changes to first few pages). Version 1.3 (Date 24 July 2017) - Throughout the book, many textual changes were made, improving readability, updating links, and including new references. The basic structure of the book has remained the same. - Modified cover picture to remove the white background. - In Ch. 2, added a short section on DEB modelling for birds and mammals. - More substantial changes are made to Ch. 3 on toxicokinetics (headings stayed the same). Readability is thoroughly improved, and I more clearly present the fact that the (total) body residue may not be the relevant dose metric for toxicity (which also has repercussions for looking at growth dilution, transfer to eggs, etc.). Corrected an oversight: the elimination rate *does* change with changes in composition (this was already correctly worked out in the Beta 1.2 version of the technical document). - Updated the references for multiple stress in the table for Section 4.5. - More substantial changes in Ch. 5 on fitting, in dealing with reproduction data. I went back to advising fitting reproduction as cumulated egg production, rather than per interval. I think this is most practical, in absence of more specific information. - Extended Ch. 7, final words, with some more recent developments. Version 2.0 (Date 9 May 2019) MAJOR UPDATE! With the development of GUTS, and especially the e-book update of 8 Dec. 2018, Roman Ashauer and myself have established a highly consistent outline for TKTD models. This outline places the concept of 'damage' in a central position. I strongly feel that it is now time to use the same general outline for DEB-based models as well. This was already included in the latest update of the DEBkiss e-book, but not yet in this e-book, nor in the associated technical document. With this version 2.0, this e-book is updated to this new conceptual framework; the previous model versions can still be derived as special cases from this framework. The case studies are still the same (using the Jager & Zimmer version of DEBtox) but an explanation is added to how this model version can be interpreted as special case. The technical document is NOT YET updated. This will need some careful consideration as also the parameter symbols need to be changed. - Most important: the old Chapters 3 and 4 (TK and TD) have been replaced by the new Chapters 3-6. The old text is largely still there, but reshuffled over the new chapters, and amended with a lot of new information and explanation. Chapter 3 provides the new conceptual outline, with damage in a central position. Chapter 4 discusses TK, Chapter 5 discusses damage in detail, and multiple stress has received its own Chapter 6. - The case sudies in Chapter 8 start with an explanation of how this model (the DEBtox version of Jager & Zimmer) should be viewed in relation to the new general framework. - Many, many small to medium textual changes, improving readability, correcting errors and adding new references. All chapters have been updated, which has led to more changes than I can keep track of in this log file. - Added an assumption for the standard DEB model in Section 2.3, namely that the allocations to growth and reproduction are converted into structural biomass and eggs with a constant conversion factor (and that a buffer can be used to translate a continuous allocation to reproduction into discrete batches of eggs). Version 2.1 (Date 21 November 2022) - Many small changes and small updates throughout the text, to reflect new publications and insights, and to clarify/correct the text. - The sub-section "Which model to use from the theory?" from Chapter 2 is now its own section 2.6. It is now extended to provide more of an overview of the various practical models that have been derived from the theory (focussing on applications in ecotoxicology). - The sub-section "Birds, mammals, and the supply-demand spectrum" is also extended to highlight some of the issues for birds and mammals (including references). Also added a dedicated sub-section on "Determinate growth" (which was mentioned in the "Metamorphosis" sub-section, but deserves its own part). Version 2.2 (Date 7 August 2023) - Changed the case study Chapter 8. The old case studies were done with the, now outdated, DEBtox model of Jager & Zimmer (2012). I now replaced this with case studies using DEBtox2019, using the same two data sets. The new case studies demonstrate the use of the parameter-space explorer algorithm (as developed for the openGUTS software), and moving-time-window extrapolation to long exposure profiles. Rather than providing more case studies in this e-book, I provide a list of relevant published case studies that can be investigated. However, in the future, I would like to add another case study, preferably one with time-varying exposure in the calibration data set. - Slight update of the "Final words" in Chapter 9, reflecting the most recent developments in the field. - Many small changes and small updates throughout the text, to reflect new publications and to clarify/correct the text. ================================================================================== Known errors that will be corrected, and updates that will be included, in the next version: - In the next version of the e-book, I hope hope to be able to include (or refer to) case studies with DEBtox2019 using experimental tests with time-varying exposure. - ...