DEBtox information
Making sense of ecotoxicity test results

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DEBtox information

DEBtox information


Welcome to the DEBtox information site

Welcome to the DEBtox information page, the site for people that want to make sense of ecotoxicity data. This site contains information on mechanistic models for the analysis of stressor effects on the life-history traits of individual organisms (and from there to higher and lower levels of biological organisation). Specifically, this site is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models from the GUTS framework.

This website constitues a node in the international DEBnet network, together with the associated site of DEBtox Research.

The mission of  is to simplify biology to get to the essence of what toxicants (and other stresses) are actually doing to organisms. Simplification is necessary if we need to gain understanding. Furthermore, we cannot expect to test even a small fraction of all possible (combinations of) toxicants, species and environmental conditions. Once we get to the essence, it is possible to make educated predictions of toxicant effects for untested chemicals, untested species, and under untested conditions.

Here, you can find information, lists of relevant publications, (links to) free e-books, and freely downloadable Matlab packages to analyse your data. Use the major categories on the top left of the screen to navigate through this site; the corresponding sub-categories will appear right next to it in the submenu.


WARNING! The 2018 course ha
s been cancelled due to personal circumstances. We are at the moment reconsidering the course contents and format, and will post more information here as soon as the plans are more concrete.

On 18 January 2018, the long-awaited GUTS e-book was released. More information on the book's support page.

                DEBnet network of experts

The Duck of Vaucanson

Upcoming courses and events

  • We unfortunately had to cancel the 2018 round of the TKTD modelling summer course DynModTox in Denmark. we hope to have more information on the next round, or somewhat different courses, in the near future.
  • For 2019, a new round of the DEB telecourse is planned, and also a classroom part followed by the international DEB symposium. This time, the location will be Brest, France. More information is provided on the symposium website, which will be filled with more information in the course of 2018.

Job opportunities for modellers

  • Postdoc position on DEB/population modelling for freshwater mussels in the US. Download description.

Latest news

  • 28 June 2018: running simulations for GUTS, I am getting confirmation that the likelihood-region method (as implemented in BYOM) is yielding exaggerated confidence intervals on  model predictions. More details on the BYOM page.
  • In 2018/2019 we will be producing a user-friendly software for GUTS. More information.
  • 27 March 2018: new paper from the GUTS project on evaluating the quality of toxicokinetic-toxicodynamic models. IEAM. 
  • 26 March 2018: the 2018 round of the TKTD modelling summer course DynModTox has been cancelled.
  • 1 February 2018: New versions of BYOM and the GUTS package. See the BYOM page.
  • 18 January 2018: The long-awaited GUTS e-book is released in Version 1.0! More information.
  • 1 November 2017: New paper from the GUTS project: Physiological modes of action across species and toxicants: the key to predictive ecotoxicology. Environ. Sci.: Processes Impacts. Open Access: 
Older news over here.

The DEBtox information site,, since July 2011