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Making sense of ecotoxicity test results



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Welcome to the DEBtox information site


Welcome to the DEBtox information page, the site for people that want to make sense of ecotoxicity data. This site contains information on mechanistic models for the analysis of stressor effects on the life-history traits of individual organisms (and from there to higher and lower levels of biological organisation). Specifically, this site is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models from the GUTS framework.

This website constitues a node in the international DEBnet network, together with the associated site of DEBtox Research.

The mission of DEBtox.info  is to simplify biology to get to the essence of what toxicants (and other stresses) are actually doing to organisms. Simplification is necessary if we need to gain understanding. Furthermore, we cannot expect to test even a small fraction of all possible (combinations of) toxicants, species and environmental conditions. Once we get to the essence, it is possible to make educated predictions of toxicant effects for untested chemicals, untested species, and under untested conditions.

Here, you can find information, lists of relevant publications, (links to) free e-books, and freely downloadable Matlab packages to analyse your data. Use the major categories on the top left of the screen to navigate through this site; the corresponding sub-categories will appear right next to it in the submenu.



The
                DEBnet network of experts


The Duck of Vaucanson

Upcoming courses and events


  • For August 2018, we are organising a new round of the TKTD modelling summer course DynModTox in Denmark. More details on the format and costs are available as of 1 November 2017, so check out the course page!
  • For 2019, a new round of the DEB telecourse is planned, and also a classroom part followed by the international DEB symposium. This time, the location will be Brest, France. More information will follow in 2018.

Job opportunities for modellers


  • RIFCON is looking for an ecological modeller to complement their population modelling and statistics team. See job description.
  • Bayer is looking for an expert ecotoxicological/ecological modeling, with explicit mention of DEB and GUTS. See job description.

Latest news


  • 1 November 2017: New paper from the GUTS project: Physiological modes of action across species and toxicants: the key to predictive ecotoxicology. Environ. Sci.: Processes Impacts. Open Access: https://doi.org/10.1039/C7EM00328E 
  • 24 July 2017: Update of the "Making sense of chemical stress" e-book. Improved readability and update with new developments.
  • 24 June 2017: Sandrine Charles wrote an excellent review of my e-book in IEAM. http://dx.doi.org/10.1002/ieam.1931 
  • 14 June 2017: New paper from the EnergyBar project: Jager T et al. Dynamic links between lipid storage, toxicokinetics and mortality in a marine copepod exposed to dimethylnaphthalene. Environ Sci Technol http://dx.doi.org/10.1021/acs.est.7b02212
  • 12 May 2017: Spotted a small error in BYOM when calculating the intervals on LC50s with the likelihood-region method. This is corrected in a small update to version 4.01.
  • 27-28 April 2017: Release of BYOM 4.0 on the BYOM page. This is a major update, with many new features, but old scripts and packages will not work anymore! All packages have been updated; the two GUTS packages have been combined, and some have been renamed for clarity. Plus, a new package has been added to fit classical dose-response curves.
Older news over here.


The DEBtox information site, www.debtox.info, since July 2011