DEBtox information
Making sense of ecotoxicity test results

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DEBtox information

DEBtox information


Welcome to the DEBtox information site

Welcome to the DEBtox information page, the site for people that want to make sense of ecotoxicity data. This site contains information on mechanistic models for the analysis of stressor effects on the life-history traits of individual organisms (and from there to higher and lower levels of biological organisation). Specifically, this site is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models from the GUTS framework.

This website constitues a node in the international DEBnet network, together with the associated site of DEBtox Research.

The mission of  is to simplify biology to get to the essence of what toxicants (and other stresses) are actually doing to organisms. Simplification is necessary if we need to gain understanding. Furthermore, we cannot expect to test even a small fraction of all possible (combinations of) toxicants, species and environmental conditions. Once we get to the essence, it is possible to make educated predictions of toxicant effects for untested chemicals, untested species, and under untested conditions.

Here, you can find information, lists of relevant publications, (links to) free e-books, and freely downloadable Matlab packages to analyse your data. Use the major categories on the top left of the screen to navigate through this site; the corresponding sub-categories will appear right next to it in the submenu.


WARNING! For users of BYOM, see the notes and warnings on the BYOM page. Specifically pertinent: the likelihood-region method yielded exaggerated confidence intervals on model predictions (fixed in version 4.2), and the LPx calculations (used with GUTS, to calculate multiplication factors on concentration profiles) is biassed when there is substantial background mortality in the calibration data set (fixed in version 4.2b

If you are working with BYOM, and would like to be notified immediately in case of errors, new versions, etc., email me and I will include you in a mailing list. I may also use this mailing list for other important developments such as new (versions) of the e-books, and new papers. This saves you the hassle of checking this website every week ;-).

                DEBnet network of experts

The Duck of Vaucanson

Upcoming courses and events

  • We unfortunately had to cancel the 2018 round of the TKTD modelling summer course DynModTox in Denmark. we hope to have more information on the next round, or somewhat different courses, in the near future.
  • For 2019, a new round of the DEB telecourse is planned, and also a classroom part followed by the international DEB symposium. This time, the location will be Brest, France. More information is provided on the symposium website, which will be filled with more information in the course of 2018.

Job opportunities for modellers

  • Postdoc position on DEB/population modelling for freshwater mussels in the US. Download description.

Latest news

  • 13 August 2018: a quick update of BYOM to v. 4.2b. This was needed as I found some errors in conjunction with GUTS package. See BYOM page for details.
  • 9 August 2018: updates of packages 'dose-response', 'acute Calanus', and 'support marecotox'. The dose-response package also has a nicer walkthrough. See BYOM page.
  • 8 August 2018: new paper out on modelling bioenergetics in early life stages of cod: 50-day free download link.
  • 7 August 2018: new version of BYOM and the GUTS package, fixing the issue with the likelihood-region method. More details on the BYOM page.
  • 28 June 2018: running simulations for GUTS, I am getting confirmation that the likelihood-region method (as implemented in BYOM) is yielding exaggerated confidence intervals on  model predictions. More details on the BYOM page.
  • In 2018/2019 we will be producing a user-friendly software for GUTS. More information.
  • 27 March 2018: new paper from the GUTS project on evaluating the quality of toxicokinetic-toxicodynamic models. IEAM. 
  • 26 March 2018: the 2018 round of the TKTD modelling summer course DynModTox has been cancelled.
Older news over here.

The DEBtox information site,, since July 2011