Welcome to the DEBtox information site
Welcome to the DEBtox information page, the
site for people that want to make sense of ecotoxicity data.
This site contains information on mechanistic models for the
analysis of stressor effects on the life-history traits of
individual organisms (and from there to higher and lower
levels of biological organisation). Specifically, this site
is about models based on animal energy budgets (DEBtox and DEBkiss) and survival models
from the GUTS framework.
This website constitues a node in the international DEBnet
network, together with the associated site of DEBtox Research.
The mission of DEBtox.info is to simplify biology to
get to the essence of what toxicants (and other stresses)
are actually doing to organisms. Simplification is necessary
if we need to gain understanding. Furthermore, we cannot
expect to test even a small fraction of all possible
(combinations of) toxicants, species and environmental
conditions. Once we get to the essence, it is possible to
make educated predictions of toxicant effects for untested
chemicals, untested species, and under untested conditions.
Here, you can find information, lists of relevant
publications, (links to) free e-books, and freely
downloadable Matlab packages to analyse your data. Use the
major categories on the top left of the screen to navigate
through this site; the corresponding sub-categories will
appear right next to it in the submenu.
WARNING! For users of BYOM, see the notes and
warnings on the BYOM page.
Specifically pertinent: the likelihood-region method
yielded exaggerated confidence intervals on model
predictions (fixed in version 4.2), and the LPx
calculations (used with GUTS, to calculate
multiplication factors on concentration profiles) is
biassed when there is substantial background
mortality in the calibration data set (fixed in
If you are working with BYOM, and would like to be
notified immediately in case of errors, new versions,
etc., email me and I will
include you in a mailing list. I may also use this
mailing list for other important developments such as
new (versions) of the e-books, and new papers. This
saves you the hassle of checking this website every
Upcoming courses and events
- We unfortunately had to cancel the 2018 round of the
TKTD modelling summer course DynModTox
in Denmark. we hope to have more information on the next
round, or somewhat different courses, in the near
- For 2019, a new round of the DEB telecourse is planned,
and also a classroom part followed by the international
DEB symposium. This time, the location will be Brest,
France. More information is provided on the symposium
website, which will be filled with more
information in the course of 2018.
Job opportunities for modellers
- Postdoc position on DEB/population modelling for
freshwater mussels in the US. Download
Older news over here.
- 7 September 2018: small update of BYOM to v. 4.2c and
updated GUTS package v. 2.3. More details on the BYOM page.
- 27 August 2018: the EFSA opinion on TKTD models is now
here. This opinion will be pivotal for the
application of GUTS and DEBtox in environmental risk
assessment (in particular for pesticides).
- 15 August 2018: update to the ring test results for
BYOM. See the guts e-book page.
- 13 August 2018: a quick update of BYOM to v. 4.2b.
This was needed as I found some errors in conjunction
with GUTS package. See BYOM page
- 9 August 2018: updates of packages 'dose-response',
'acute Calanus', and 'support marecotox'. The
dose-response package also has a nicer walkthrough.
See BYOM page.
- 8 August 2018: new paper out on modelling
bioenergetics in early life stages of cod: 50-day
free download link.
- 7 August 2018: new version of BYOM and the GUTS
package, fixing the issue with the likelihood-region
method. More details on the BYOM
- 28 June 2018: running simulations for GUTS, I am
getting confirmation that the likelihood-region method
(as implemented in BYOM) is yielding exaggerated
confidence intervals on model predictions. More
details on the BYOM page.
- In 2018/2019 we will be producing a user-friendly
software for GUTS. More
- 27 March 2018: new paper from the GUTS
project on evaluating the quality of
toxicokinetic-toxicodynamic models. IEAM. https://doi.org/10.1002/ieam.2026
- 26 March 2018: the 2018 round of the TKTD modelling
summer course DynModTox
has been cancelled.